Improvement of the bioavailability of many plant extracts becomes one of the key issues of bio-efficacy and therapeutic value of this extract.
Many herbal extracts despite their extraordinary potential in in-vitro research, demonstrate less or no in-vivo actions, and later even less efficacy in clinical trials, due to their poor lipid solubility or improper molecular size, ultimately resulting in poor absorption and poor bioavailability.
The concept of ‘bioavailability enhancers’ is derived from the traditional system of Ayurveda (science of life). In Ayurveda, black pepper, long pepper, and ginger known as “Trikatu,” and are used as bio-enhancers.
A ‘bio-enhancer’ is an agent capable of enhancing the bio-availability and bio-efficacy of an extract with which it is combined, without any pharmacological intervention.
For example, the black pepper extract piperine, was found to increase bioavailability of curcumin (active ingredient of turmeric) by ten times. It was additionally noted that piperine did not increase the bioavailability of all herbal extracts.
There are several mechanisms of action by which herbal bio-enhancers act. Different herbal bio-enhancers may have same or different mechanisms of action. Nutritional bio-enhancers enhance absorption by acting on the gastrointestinal tract.
The composition of ingredients and percentages of “plus” compounds may be different for various plant extracts (5%-25%) according to the bio-availably of the plant.
Most of the plants of the of our bio-enhancing herbs contain additional health benefits.
Angelica Sinensis (Dong Ouai) root extract.
In Traditional Chinese Medicine (TCM), Astragalus roots are paired with small percentages of Dong Quai, Licorice and Ginseng to improve bio-efficacy.
Licorice root extract.
The absorption-enhancing activity of glycyrrhizin (saponin found in Licorice roots) is known to increase absorption and work as bio-enhancer.
Citrus peels blend extract.
Quercetin is a flavonoid found in citrus fruits. Quercetin has been shown to exhibit a wide range of beneficial biological activities including antioxidant, radical scavenging, anti-inflammatory, anti-atherosclerotic, anti-tumoral and anti-viral effects. Quercetin has been shown to increase the bioavailability and bio-efficacy of a number of herbal extracts.
Soybean extract is the source Genistein that belongs to the isoflavone class of flavonoids. It has been shown to increase bio-availably (AUC) by 40-60%.
Grapefruit peels extract.
Grapefruit extract is the source of Naringin, the major flavonoid glycoside, which exerts a variety of pharmacological effects such as antioxidant, blood lipid lowering and anticarcinogenic activities. It also has been shows to increase bio-availability (AUC) by 40-50%.
Ginger roots extract
Ginger has a powerful effect on the mucosal membrane of the gastrointestinal tract. It regulates the intestinal function to facilitate absorption and bio-availability for many herbal extracts.
Black garlic extract
Allicin, the active bioenhancer from garlic extract.
Moringa leaf extract
Nitrile glycosides and its derivatives are components derived from the pods of Moringa oleifera. They are reported to promote biological activity and bioavailability.
Black cumin is an effective gastric stimulant which enhances bio-availability. Various volatile oils, luteolin, and other flavonoids have been attributed to enhancing its bio-availability and bio-enhancement.
Black pepper extract.
Piperine extract, from black pepper, has been observed to increase the bio-availability of many herbal extracts, especially Turmeric and Galangal roots extracts, up to ten times of it’s typical potency. It may increase the absorption of drugs in the gastrointestinal tract, or inhibit enzymes responsible for drug metabolism, particularly in the liver.